Acetyl chloride → 8-Fluoro-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl acetate
반응식
[F:1][C:2]1[CH:3]=[C:4]([OH:13])[CH:5]=[C:6]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8][CH2:7]2.[C:14](Cl)(=[O:16])[CH3:15]>C(Cl)Cl>[C:14]([O:13][C:4]1[CH:5]=[C:6]2[C:11](=[C:2]([F:1])[CH:3]=1)[NH:10][C:9](=[O:12])[CH2:8][CH2:7]2)(=[O:16])[CH3:15]참가 물질
4
실험 절차
Crude 8-fluoro-6-hydroxy-3,4-dihydroquinolin-2(1H)-one (0.574 g) was treated with acetyl chloride (330 mg) and TEA (0.68 mL) in DCM (8 mL) over 3 h. After aqueous work-up with EtOAc/water, the crude product was purified with a flash column chromatography to afford the desired product (382 mg) as colorless solids.
후처리
- customAfter aqueous work-up with EtOAc/water, the crude product was purified with a flash column chromatography
출처 및 근거
- ORD 기록
- ord-075ad78a789047b3b64bee781d4a979b
- 출처 데이터셋
- uspto-grants-2016_04
- 특허 번호
- US09315462B2
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