Morpholine → HCID 86673493, 화합물

HRID 629006노트

반응식

HRID 629006 반응식
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([O:9][CH2:10][CH3:11])=[CH:4][N:3]=1.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1.[NH4+].[Cl-]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[N:7]=[C:6]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:5]([O:9][CH2:10][CH3:11])=[CH:4][N:3]=1

참가 물질

5

반응물 3

HCID 8083MorpholineHCID 25517Ammonium ChlorideHCID 155652702,4-Dichloro-5-ethoxypyrimidine

생성물 1

HCID 86673493HCID 86673493, 화합물수율 73.5%

시약·촉매·용매 1

HCID 1140Toluene용매2회

실험 절차

2,4-dichloro-5-ethoxy-pyrimidin (2.83 g, 1.0 eq) was stirred in toluene (20 ml) and a solution of morpholine (1.93 ml, 1.5 eq) in toluene (20 ml) was added dropwise at −10˜0° C. After stirring the resulting solution overnight at r.t., NH4Cl(aq) was added to the solution and the solution was extracted with EA. The combined organic layers were washed with brine, dried and evaporated in vacuo. A product was obtained as a white solid (2.7 g, 73.5%).

후처리

  1. extractionthe solution was extracted with EA
  2. washThe combined organic layers were washed with brine
  3. customdried
  4. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-d184133309004e728c3ac474b799dce2
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09315491B2

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