Methanesulfonyl chloride → N-[4-(4-Chloro-5-methylsulfanyl-6-morpholin-4-yl-pyrimidin-2-yl)-phenyl]-methanesulfonamide

HRID 629009노트

반응식

HRID 629009 반응식
[Cl:1][C:2]1[C:7]([S:8][CH3:9])=[C:6]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[N:5]=[C:4]([C:16]2[CH:21]=[CH:20][C:19]([NH2:22])=[CH:18][CH:17]=2)[N:3]=1.[CH3:23][S:24](Cl)(=[O:26])=[O:25]>C(Cl)Cl>[Cl:1][C:2]1[C:7]([S:8][CH3:9])=[C:6]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[N:5]=[C:4]([C:16]2[CH:21]=[CH:20][C:19]([NH:22][S:24]([CH3:23])(=[O:26])=[O:25])=[CH:18][CH:17]=2)[N:3]=1

참가 물질

4

반응물 2

HCID 31297Methanesulfonyl chlorideHCID 86673495HCID 86673495, 화합물

생성물 1

HCID 86673496N-[4-(4-Chloro-5-methylsulfanyl-6-morpholin-4-yl-pyrimidin-2-yl)-phenyl]-methanesulfonamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of 4-(4-chloro-5-methylsulfanyl-6-morpholin-4-yl-pyrimidin-2-yl)-phenylamine (30 mg, 0.091 mmol.), methanesulfonyl chloride (15.5 mg, 0.136 mmol, 1.5 eq.) and CH2Cl2 was added to the reaction vessel and flushed with argon. The reaction mixture was stirred at r.t. for 2 hrs. The reaction mixture was partitioned between CH2Cl2 and NaHCO3 (aq), the organic layer was washed with brine, dried over MgSO4, filtered and evaporated in vacuo. A white solid of 30.3 mg (82.1%) was obtained as the product.

후처리

  1. additionwas added to the reaction vessel
  2. customflushed with argon
  3. customThe reaction mixture was partitioned between CH2Cl2 and NaHCO3 (aq)
  4. washthe organic layer was washed with brine
  5. dry with materialdried over MgSO4
  6. filtrationfiltered
  7. customevaporated in vacuo
  8. customA white solid of 30.3 mg (82.1%) was obtained as the product

출처 및 근거

ORD 기록
ord-69b170ead6e84c82943c147b07956a80
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09315491B2

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