Urea → 5-Methoxypyrimidine-2,4,6-triol

HRID 629027

반응식

HRID 629027 반응식
O(C)[Na].[CH3:4][O:5][CH:6]([C:11]([O:13]C)=O)[C:7]([O:9]C)=O.[NH2:15][C:16]([NH2:18])=[O:17]>CCO>[OH:13][C:11]1[NH:18][C:16](=[O:17])[NH:15][C:7](=[O:9])[C:6]=1[O:5][CH3:4]

참가 물질

5

반응물 3

HCID 1176UreaHCID 78718Dimethyl methoxymalonateHCID 178418582HCID 178418582, 화합물

생성물 1

HCID 673031125-Methoxypyrimidine-2,4,6-triol수율 99%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
100 °C

실험 절차

The NaOCH3 (8.5 g, 157 mmole), was added to a stirred solution of dimethyl 2-methoxymalonate (10.2 g, 62.91 mmole), urea (2.5 g, 41.7 mmole), and EtOH (80 ml). The reaction mixture was heated to 100° C. for 4 hrs, then the reaction was evaporated to remove the solvent. Water was added to the mixture and then concentrated HCl was added. The pH of the mixture was adjusted to ca. 3˜4. The mixture was filtered and wash water and acetone. After drying in vacuo, it gave a product (99%).

후처리

  1. customthe reaction was evaporated
  2. customto remove the solvent
  3. additionWater was added to the mixture
  4. additionconcentrated HCl was added
  5. filtrationThe mixture was filtered
  6. washwash water and acetone
  7. customAfter drying in vacuo, it

출처 및 근거

ORD 기록
ord-1d949d18dba545aa9d399ca3657db60d
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09315491B2

연결된 노트

불러오는 중…