4-Benzyl-1,3-oxazolidin-2-one → 2-(4-Benzyloxy-3-chloro-phenyl)-cyclopropane carboxylic acid

HRID 62912

반응식

HRID 62912 반응식
C([C@@H]1COC(=O)N1[C:14]([CH:16]1[CH2:18][CH:17]1[C:19]1[CH:24]=[CH:23][C:22]([O:25][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[C:21]([Cl:33])[CH:20]=1)=[O:15])C1C=CC=CC=1.C(C1C[O:44]C(=O)N1)C1C=CC=CC=1>>[CH2:26]([O:25][C:22]1[CH:23]=[CH:24][C:19]([CH:17]2[CH2:18][CH:16]2[C:14]([OH:15])=[O:44])=[CH:20][C:21]=1[Cl:33])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

참가 물질

3

반응물 2

HCID 5596684-Benzyl-1,3-oxazolidin-2-oneHCID 90118050(R)-4-Benzyl-3-[2-(4-benzyloxy-3-chloro-phenyl)-cyclopropanecarbonyl]-oxazolidin-2-on

생성물 1

HCID 901182252-(4-Benzyloxy-3-chloro-phenyl)-cyclopropane carboxylic acid

실험 절차

(R)-4-benzyl-3-[2-(4-benzyloxy-3-chloro-phenyl)-cyclopropanecarbonyl]-oxazolidin-2-on (918 mg, 1.98 mmol) obtained in Step C was reacted in the same manner as in Step A of Preparation Example 59 to obtain the mixture (650 mg) of the title compound and 4-benzyloxazolidin-2-on.

출처 및 근거

ORD 기록
ord-cb21e834ef3c4528974c458211dd7386
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447044B2

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