5-Bromo-benzo[b]thiophene-2-carbaldehyde → 5-Butyl-2-formylbenzothiophene

반응식

Br[C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([CH:10]=[O:11])=[CH:7][C:6]=2[CH:12]=1.[CH2:13]([B-](F)(F)F)[CH2:14][CH2:15][CH3:16].[K+]>>[CH2:13]([C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([CH:10]=[O:11])=[CH:7][C:6]=2[CH:12]=1)[CH2:14][CH2:15][CH3:16]

참가 물질

반응물 2

HCID 6180355-Bromo-benzo[b]thiophene-2-carbaldehyde

HCID 23693579Potassium Butyltrifluoroborate

생성물 1

HCID 1182289595-Butyl-2-formylbenzothiophene수율 85%

실험 절차

The compound was prepared as in Example 3.1 using 5-bromo-2-formylbenzothiophene (241 mg, 1.0 mmol) in place of 5-bromo-2-formylfuran and potassium butyltrifluoroborate (246 mg, 1.5 mmol) in place of hexylboronic acid to give 5-butyl-2-formylbenzothiophene (185 mg, 85%). Used without further characterization.

출처 및 근거

ORD 기록: ord-0ad649dbcba6473798dfb99177ece574
출처 데이터셋: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09315495B2

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