4-Benzyl-1,3-oxazolidin-2-one → 2-(4-Benzyloxy-3-chloro-phenyl)-cyclopropane carboxylic acid methyl ester

HRID 62915

반응식

HRID 62915 반응식
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]2[CH2:17][CH:16]2[C:18]([OH:20])=[O:19])=[CH:11][C:10]=1[Cl:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:22](C1COC(=O)N1)C1C=CC=CC=1>>[CH3:22][O:19][C:18]([CH:16]1[CH2:17][CH:15]1[C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[C:10]([Cl:21])[CH:11]=1)=[O:20]

참가 물질

3

반응물 2

HCID 5596684-Benzyl-1,3-oxazolidin-2-oneHCID 901182252-(4-Benzyloxy-3-chloro-phenyl)-cyclopropane carboxylic acid

생성물 1

HCID 901183022-(4-Benzyloxy-3-chloro-phenyl)-cyclopropane carboxylic acid methyl ester수율 60%

실험 절차

The mixture (85 mg) of 2-(4-benzyloxy-3-chloro-phenyl)-cyclopropane carboxylic acid and 4-benzyloxazolidin-2-on obtained in Step A was reacted in the same manner as in Step B of Preparation Example 59 to obtain the title compound (54 mg, two-step yield 60%).

출처 및 근거

ORD 기록
ord-0fbf27ca1b824917bd2391ec9e746adc
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447044B2

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