Ethyl 3-(4-hydroxyphenyl)-2-methylpropanoate → 3-[4-(2-Isopropylsulfanyl-5-methyl-pyridin-3-ylmethoxy)phenyl]-2-methyl-propionic acid ethyl ester

HRID 62921

반응식

HRID 62921 반응식
Cl[CH2:2][C:3]1[C:4]([S:10][CH:11]([CH3:13])[CH3:12])=[N:5][CH:6]=[C:7]([CH3:9])[CH:8]=1.[CH2:14]([O:16][C:17](=[O:28])[CH:18]([CH3:27])[CH2:19][C:20]1[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][CH:21]=1)[CH3:15]>>[CH2:14]([O:16][C:17](=[O:28])[CH:18]([CH3:27])[CH2:19][C:20]1[CH:21]=[CH:22][C:23]([O:26][CH2:2][C:3]2[C:4]([S:10][CH:11]([CH3:13])[CH3:12])=[N:5][CH:6]=[C:7]([CH3:9])[CH:8]=2)=[CH:24][CH:25]=1)[CH3:15]

참가 물질

3

반응물 2

HCID 20748401Ethyl 3-(4-hydroxyphenyl)-2-methylpropanoateHCID 901182773-Chloromethyl-2-isopropylsulfanyl-5-methyl-pyridine

생성물 1

HCID 901182133-[4-(2-Isopropylsulfanyl-5-methyl-pyridin-3-ylmethoxy)phenyl]-2-methyl-propionic acid ethyl ester수율 33%

실험 절차

3-Chloromethyl-2-isopropylsulfanyl-5-methyl-pyridine (0.02 g, 0.09 mmol) obtained in Step D of Preparation Example 30 and 3-(4-hydroxy-phenyl)-2-methyl-propionic acid ethyl ester obtained in Step B of Preparation Example 3 were reacted in the same manner as in Step A of Example 1 to obtain the title compound (0.012 g, 33%).

후처리

  1. customwere reacted in the same manner as in Step A of Example 1

출처 및 근거

ORD 기록
ord-9eb834cc685249e19de8b80635f71707
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447044B2

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