4-Chlorophenylboronic acid → 6-Bromo-3-(4-chlorophenyl)imidazo[1,2-a]pyridine

반응식

[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8](I)=[CH:9][N:10]=2)[CH:7]=1.[Cl:12][C:13]1[CH:18]=[CH:17][C:16](B(O)O)=[CH:15][CH:14]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C:16]3[CH:17]=[CH:18][C:13]([Cl:12])=[CH:14][CH:15]=3)=[CH:9][N:10]=2)[CH:7]=1

참가 물질

반응물 2

HCID 742994-Chlorophenylboronic acid

HCID 220316326-Bromo-3-iodoimidazo(1,2-a)pyridine

생성물 1

HCID 898267166-Bromo-3-(4-chlorophenyl)imidazo[1,2-a]pyridine

실험 절차

The title compound, light yellow solid (0.28 g, 42%), MS (ISP) m/z=307.3 [(M+H)+], mp 157° C., was prepared in accordance with the general method of intermediate E from commercially available 6-bromo-3-iodoimidazo[1,2-a]pyridine (0.7 g, 2.17 mmol) and commercially available 4-chloro-phenylboronic acid (0.34 g, 2.17 mmol).

출처 및 근거

ORD 기록: ord-5d3491c555bf4797b0fbc54bcd67e821
출처 데이터셋: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09315502B2

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