4-(Trifluoromethyl)phenylboronic acid → 6-Bromo-3-(4-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridine

반응식

[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8](I)=[CH:9][N:10]=2)[CH:7]=1.[F:12][C:13]([F:24])([F:23])[C:14]1[CH:19]=[CH:18][C:17](B(O)O)=[CH:16][CH:15]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C:17]3[CH:18]=[CH:19][C:14]([C:13]([F:24])([F:23])[F:12])=[CH:15][CH:16]=3)=[CH:9][N:10]=2)[CH:7]=1

참가 물질

반응물 2

HCID 27343894-(Trifluoromethyl)phenylboronic acid

HCID 220316326-Bromo-3-iodoimidazo(1,2-a)pyridine

생성물 1

HCID 901898656-Bromo-3-(4-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridine

실험 절차

The title compound, light brown solid (0.3 g, 40%), MS (ISP) m/z=341.4 [(M+H)+], mp 151° C., was prepared in accordance with the general method of intermediate E from commercially available 6-bromo-3-iodoimidazo[1,2-a]pyridine (0.7 g, 2.17 mmol) and commercially available 4-trifluoromethyl-phenylboronic acid (0.45 g, 2.38 mmol).

출처 및 근거

ORD 기록: ord-cae74930a4ae4a288f644743384831b1
출처 데이터셋: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09315502B2

반응 노트

불러오는 중…