6-Bromo-3-phenyl-imidazo[1,2-a]pyridine → 3-Phenyl-6-(2-phenyl-2H-pyrazol-3-yl)-imidazo[1,2-a]pyridine
반응식
Br[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[CH:9][N:10]=2)[CH:7]=1.[C:17]1([N:23]2[C:27](B3OC(C)(C)C(C)(C)O3)=[CH:26][CH:25]=[N:24]2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[C:11]1([C:8]2[N:6]3[CH:7]=[C:2]([C:27]4[N:23]([C:17]5[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=5)[N:24]=[CH:25][CH:26]=4)[CH:3]=[CH:4][C:5]3=[N:10][CH:9]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1참가 물질
3
실험 절차
The title compound, off-white solid (48 mg, 39%), MS (ISP) m/z=337.5 [(M+H)+], mp 139° C., was prepared in accordance with the general method of example 1 from 6-bromo-3-phenyl-imidazo[1,2-a]pyridine (intermediate G) (0.1 g, 0.366 mmol) and 1-phenyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole (intermediate D) (0.12 g, 0.44 mmol).
출처 및 근거
- ORD 기록
- ord-a7cc2a68b95248f2b46b5a25ae0f775b
- 출처 데이터셋
- uspto-grants-2016_04