Water → 5-bromo-2-hydroxy-4-methylbenzoic acid

HRID 629330노트

반응식

HRID 629330 반응식
[OH:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Br:12]Br.O>C(O)(=O)C>[Br:12][C:8]1[C:9]([CH3:11])=[CH:10][C:2]([OH:1])=[C:3]([CH:7]=1)[C:4]([OH:6])=[O:5]

참가 물질

5

반응물 3

HCID 962WaterHCID 57882-Hydroxy-p-toluic acidHCID 24408Bromine

생성물 1

HCID 2439345-bromo-2-hydroxy-4-methylbenzoic acid

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a solution of 2-hydroxy-4-methylbenzoic acid (5.00 g) in acetic acid (70.0 mL) was added dropwise bromine (1.68 mL), and the mixture was stirred at room temperature for 5.5 hr. To the reaction mixture was added water, and the precipitate was collected by filtration, and dried under reduced pressure to give the title compound (6.78 g).

후처리

  1. filtrationthe precipitate was collected by filtration
  2. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-33f50400cbf0496d9ad10fd87bd16de3
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09315458B2

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