Potassium Carbonate → Methyl 3-chloro-2-hydroxy-4-(trifluoromethyl)benzoate

HRID 629356노트

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HRID 629356 반응식
[Cl:1][C:2]1[C:3]([O:16]C(OC)=O)=[C:4]([CH:9]=[CH:10][C:11]=1[C:12]([F:15])([F:14])[F:13])[C:5]([O:7][CH3:8])=[O:6].C(=O)([O-])[O-].[K+].[K+]>CO>[Cl:1][C:2]1[C:3]([OH:16])=[C:4]([CH:9]=[CH:10][C:11]=1[C:12]([F:14])([F:15])[F:13])[C:5]([O:7][CH3:8])=[O:6]

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 118468126Methyl 3-chloro-2-[(methoxycarbonyl)oxy]-4-(trifluoromethyl)benzoate

생성물 1

HCID 118468129Methyl 3-chloro-2-hydroxy-4-(trifluoromethyl)benzoate수율 71.6%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
15 °C

실험 절차

To a solution of methyl 3-chloro-2-[(methoxycarbonyl)oxy]-4-(trifluoromethyl)benzoate (6.00 g) in methanol (60.0 mL) was added potassium carbonate (8.00 g), and the mixture was stirred at 15° C. for 16 hr. The reaction mixture was filtered, the filtrate was neutralized with 1N hydrochloric acid, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (3.50 g).

후처리

  1. filtrationThe reaction mixture was filtered
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with saturated brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-5d83b9ed898f4d198237d5fd7d22ea48
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09315458B2

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