Thionyl Chloride → 5-(Chloromethyl)-2-methylpyridine hydrochloride
반응식
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8]O)=[CH:4][CH:3]=1.S(Cl)([Cl:12])=O>C1COCC1>[ClH:12].[Cl:12][CH2:8][C:5]1[CH:4]=[CH:3][C:2]([CH3:1])=[N:7][CH:6]=1참가 물질
4
실험 절차
To a solution of (6-methylpyridin-3-yl)methanol (1.24 g) in THF (12.4 mL) was added thionyl chloride (1.10 mL) under ice-cooling, and the mixture was stirred overnight at room temperature. The reaction mixture was concentrated under reduced pressure, and the obtained residue was suspended in ethyl acetate. The precipitate was collected by filtration, and washed with ethyl acetate-hexane to give the title compound (1.64 g).
후처리
- temperaturecooling
- concentrationThe reaction mixture was concentrated under reduced pressure
- filtrationThe precipitate was collected by filtration
- washwashed with ethyl acetate-hexane
출처 및 근거
- ORD 기록
- ord-2f95570a6b704641abd4e40931c3ffec
- 출처 데이터셋
- uspto-grants-2016_04
- 특허 번호
- US09315458B2
반응 노트
불러오는 중…