2-Hydroxy-4-vinyl-benzoic acid methyl ester → Methyl 4-ethyl-2-hydroxybenzoate

HRID 629470

반응식

HRID 629470 반응식
[OH:1][C:2]1[CH:11]=[C:10]([CH:12]=[CH2:13])[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]>C(O)C.[C].[Pd]>[CH2:12]([C:10]1[CH:9]=[CH:8][C:3]([C:4]([O:6][CH3:7])=[O:5])=[C:2]([OH:1])[CH:11]=1)[CH3:13]

참가 물질

4

반응물 1

HCID 200893762-Hydroxy-4-vinyl-benzoic acid methyl ester

생성물 1

HCID 54092218Methyl 4-ethyl-2-hydroxybenzoate수율 61.2%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매

실험 절차

To a solution of methyl 2-hydroxy-4-vinylbenzoate (2.31 g) in ethanol (25.0 mL) was added palladium-carbon (1.38 g), and the mixture was stirred overnight at room temperature under hydrogen atmosphere. The insoluble substance was removed by filtration, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by NH silica gel column chromatography (ethyl acetate/hexane) to give the title compound (1.43 g).

후처리

  1. customThe insoluble substance was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe obtained residue was purified by NH silica gel column chromatography (ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-dbf89bd7c938424387e80510ea411f7a
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09315458B2

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