Tert-Butyl nitrite → 1,3-Dibromo-2,5-dichlorobenzene

HRID 629504노트

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HRID 629504 반응식
[Br:1][C:2]1[C:8]([Cl:9])=[C:7]([Br:10])[CH:6]=[C:5]([Cl:11])[C:3]=1N.N(OC(C)(C)C)=O>CCO>[Br:1][C:2]1[CH:3]=[C:5]([Cl:11])[CH:6]=[C:7]([Br:10])[C:8]=1[Cl:9]

참가 물질

4

반응물 2

HCID 10906Tert-Butyl nitriteHCID 2625112,4-Dibromo-3,6-dichloroaniline

생성물 1

HCID 140296671,3-Dibromo-2,5-dichlorobenzene

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
50 °C

실험 절차

A stirred mixture of 2,4-dibromo-3,6-dichloroaniline (5.0 g), tert-Butyl nitrite (3.3 g) and EtOH (50 mL) was heated in a sealed tube at 50° C. for 2 hrs. The mixture was concentrated and the residue was purified by silica gel flash chromatography (hexanes eluant) to afford the title compound. MS m/z: 303 (M+H)+.

후처리

  1. concentrationThe mixture was concentrated
  2. customthe residue was purified by silica gel flash chromatography (hexanes eluant)

출처 및 근거

ORD 기록
ord-901e293ba30046ac817796478b56fe77
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09314464B2

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