Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 629599생성일: 2026년 10월 26일
4-Chloro-3-nitrobenzenesulfonamide → 4-[1-(2-Methoxy-ethyl)-piperidin-4-ylamino]-3-nitro-benzenesulfonamide
https://huagongshe.com/reaction/629599
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Chloro-3-nitrobenzenesulfonamide | HCID 7324 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 1-(2-Methoxyethyl)piperidin-4-amine | HCID 20119121 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 4-[1-(2-Methoxy-ethyl)-piperidin-4-ylamino]-3-nitro-benzenesulfonamide | HCID 68406613 | — |
반응 단계
1-(2-Methoxy-ethyl)-piperidin-4-ylamine (2.01 g) and triethylamine (3.24 mL, 2.35 g) were added to 1,4-dioxane (60 mL). 4-Chloro-3-nitrobenzenesulfonamide (2.50 g) was added, and the mixture was heated to 90° C. for 16 hours. The mixture was cooled and the material purified by flash column chromatography on silica gel using 10% methanol in dichloromethane.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09315488B2 |
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| 출처 데이터셋 | uspto-grants-2016_04 |
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| ORD ID | ord-1158022bd4ec41c8aca24c74d2ca769e |
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| 출처 메모 | uspto-grants-2016_04 |
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