Diethylamine → HCID 59589465, 화합물

HRID 630052노트

반응식

HRID 630052 반응식
Br[CH2:2][C:3]1[CH:4]=[CH:5][C:6]([Cl:12])=[C:7]([CH:11]=1)[C:8]([O-:10])=[O:9].[CH2:13]([NH:15][CH2:16][CH3:17])[CH3:14].[C:18](=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Cl:12][C:6]1[CH:5]=[CH:4][C:3]([CH2:2][N:15]([CH2:16][CH3:17])[CH2:13][CH3:14])=[CH:11][C:7]=1[C:8]([O:10][CH3:18])=[O:9]

참가 물질

5

반응물 3

HCID 8021DiethylamineHCID 11430Potassium CarbonateHCID 86647906HCID 86647906, 화합물

생성물 1

HCID 59589465HCID 59589465, 화합물수율 99.5%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 5-(bromomethyl)-2-chlorobenzoate (4.0 g, 15.6 mmol), diethylamine (5 mL, 48.1 mmol), and potassium carbonate (4.3 g, 31.2 mmol) in acetone (60 mL) was stirred at room temperature for 2 days. The solid material was removed by filtration. The filtrate was recovered, evaporated, and dried in vacuo, affording methyl 2-chloro-5-[(diethylamino)methyl]benzoate (3.97 g, 99% yield). The product was used without further purification.

후처리

  1. customThe solid material was removed by filtration
  2. customThe filtrate was recovered
  3. customevaporated
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-4dec5eee756a4bc4863ca84844f5ae36
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09315521B2

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