Thionyl Chloride → 5-chloro-4-(chloromethyl)-1-methyl-1H-imidazole hydrochloride

HRID 630112노트

반응식

HRID 630112 반응식
[Cl:1][C:2]1[N:6]([CH3:7])[CH:5]=[N:4][C:3]=1[CH2:8]O.S(Cl)([Cl:12])=O>ClCCl>[ClH:1].[Cl:1][C:2]1[N:6]([CH3:7])[CH:5]=[N:4][C:3]=1[CH2:8][Cl:12]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 21657108(5-chloro-1-methyl-1H-imidazol-4-yl)methanol

생성물 1

HCID 668208135-chloro-4-(chloromethyl)-1-methyl-1H-imidazole hydrochloride수율 99%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of (5-chloro-1-methyl-1H-imidazol-4-yl)methanol (397 mg, 2.7 mmol) in anhydrous dichloromethane (20 mL) was added thionyl chloride (1 mL). The mixture was stirred at room temperature for 2 hours. Dichloromethane was evaporated and then co-evaporated with toluene (2×10 mL). The residue was dried in vacuo, affording 5-chloro-4-(chloromethyl)-1-methyl-1H-imidazole hydrochloride (550 mg, 99% yield). The product was used without further purification.

후처리

  1. customDichloromethane was evaporated
  2. customThe residue was dried in vacuo

출처 및 근거

ORD 기록
ord-5385161c5b3b45088605459f7e606b2e
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09315521B2

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