Bromine → Ethyl 2-bromo-3-oxopentanoate
반응식
[O:1]=[C:2]([CH2:9][CH3:10])[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5].[Br:11]Br>O>[Br:11][CH:3]([C:2](=[O:1])[CH2:9][CH3:10])[C:4]([O:6][CH2:7][CH3:8])=[O:5]참가 물질
4
반응 조건
- 온도
- 0 °C
실험 절차
To a 0° C. solution of ethyl 3-oxopentanoate (5.0 mL, 34.7 mmol) in water (30 mL) was added bromine (1.8 mL, 35.0 mmol) via syringe pump addition (0.5 h). The mixture was stirred at 0° C. for 0.5 hour. The solution was extracted with EtOAc (2×35 mL). The organic extracts were combined, dried over MgSO4, filtered, evaporated, and dried in vacuo, affording ethyl 2-bromo-3-oxopentanoate (7.3 g, 94% yield). The product was used without further purification.
후처리
- additionpump addition (0.5 h)
- extractionThe solution was extracted with EtOAc (2×35 mL)
- dry with materialdried over MgSO4
- filtrationfiltered
- customevaporated
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-9525c3802dac46459d16187f60ed3380
- 출처 데이터셋
- uspto-grants-2016_04
- 특허 번호
- US09315521B2
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