Chloride → N-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-methoxyphenyl]acrylamide

HRID 630412노트

반응식

HRID 630412 반응식
[Cl-].C(CC(CC)(NC(C)C)C)C.[Si:13]([O:20][CH2:21][C:22]1[C:27]([O:28][CH3:29])=[CH:26][C:25]([NH:30][C:31](=[O:34])[CH:32]=[CH2:33])=[C:24](Cl)[CH:23]=1)([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14]>>[Si:13]([O:20][CH2:21][C:22]1[CH:23]=[CH:24][C:25]([NH:30][C:31](=[O:34])[CH:32]=[CH2:33])=[CH:26][C:27]=1[O:28][CH3:29])([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:14])[CH3:15]

참가 물질

4

반응물 3

HCID 312ChlorideHCID 67145019N-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-chloro-5-methoxyphenyl]-acrylamideHCID 129867302Diethyldiisopropylamine

생성물 1

HCID 67469526N-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-methoxyphenyl]acrylamide

실험 절차

Obtained as a solid (63%) from [4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-methoxyphenyl]amine (intermediate 99; 5 g, 18.7 mmol), acryloil chloride (1.98 mL, 24.28 mmol) and diethyldiisopropylamine (4.9 mL, 28.06 mmol) following the experimental procedure as described in intermediate 40. The crude obtained was purified by column chromatography with silica gel, eluting with methylene chloride.

후처리

  1. customThe crude obtained
  2. customwas purified by column chromatography with silica gel
  3. washeluting with methylene chloride

출처 및 근거

ORD 기록
ord-cdbbf9f8ce6f4afcaeb5d1ad7d278e1e
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09315463B2

반응 노트

불러오는 중…