Benzenemethanamine, 3,4-dichloro- → Methyl 3-[(3,4-dichlorobenzyl)amino]pyridine-4-carboxylate

HRID 63048

반응식

HRID 63048 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[CH2:5][NH2:6].Br[C:12]1[CH:21]=[N:20][CH:19]=[CH:18][C:13]=1[C:14]([O:16][CH3:17])=[O:15]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[CH2:5][NH:6][C:18]1[CH:19]=[N:20][CH:21]=[CH:12][C:13]=1[C:14]([O:16][CH3:17])=[O:15]

참가 물질

3

반응물 2

HCID 1608Benzenemethanamine, 3,4-dichloro-HCID 2762700Methyl 3-bromoisonicotinate

생성물 1

HCID 86728202Methyl 3-[(3,4-dichlorobenzyl)amino]pyridine-4-carboxylate수율 73%

실험 절차

The title compound was prepared in 73% yield from 3,4-dichlorobenzylamine and methyl 3-bromoisonicotinate according to the procedure for Preparation 4A. 1H NMR (400 MHz, CDCl3): δ 8.10 (s, 1H), 7.95 (d, 1H, J=5.1 Hz), 7.87 (br s, 1H), 7.65 (d, 1H, J=5.1 Hz), 7.42 (d, 1H, J=8.7 Hz), 7.39 (s, 1H), 7.18 (dd, 1H, J=8.2 Hz), 4.48 (d, 2H, J=6.0 Hz), 3.91 (s, 3H). [M+H] calc'd for C14H12Cl2N2O2, 311, 313. found 311, 313.

출처 및 근거

ORD 기록
ord-4cb76b94dd544cc79c06398b46c46cc5
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447045B2

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