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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 630526생성일: 2026년 10월 27일

2-Bromo-4-chloropyridine → (1-(5-(4-Chloropyridin-2-yl)pyrimidin-2-yl)-3-(methylthio)-1H-indol-6-yl)(morpholino)methanone

https://huagongshe.com/reaction/630526

반응식

참여 물질

역할이름HCID투입량
반응물2-Bromo-4-chloropyridineHCID 2762836—
반응물(1-(5-Bromopyrimidin-2-yl)-3-(methylthio)-1H-indol-6-yl)(morpholino)methanoneHCID 118666053—
반응물(1-(5-(4-(2-Hydroxypropan-2-yl)pyridin-2-yl)pyrimidin-2-yl)-3-(methylthio)-1H-indol-6-yl)(morpholino)methanoneHCID 118666145—
생성물(1-(5-(4-Chloropyridin-2-yl)pyrimidin-2-yl)-3-(methylthio)-1H-indol-6-yl)(morpholino)methanoneHCID 118676840—

반응 단계

Coupling of (1-(5-bromopyrimidin-2-yl)-3-(methylthio)-1H-indol-6-yl)(morpholino) methanone and 2-bromo-4-chloropyridine analogously in an analogous manner as described for 289a). White solid. Yield: 1.7 g (79% of theory)

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09315490B2
출처 데이터셋uspto-grants-2016_04
ORD IDord-a1e9f8a7468e4ecc957336a85e4e9c85
출처 메모uspto-grants-2016_04