2-Aminomethyl-1,4-benzodioxane → 3-[(2,3-Dihydro-1,4-benzodioxin-2-ylmethyl)amino]pyridine-4-carboxylic acid

HRID 63071

반응식

HRID 63071 반응식
[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][CH2:3][CH:2]1[CH2:11][NH2:12].F[C:14]1[CH:22]=[N:21][CH:20]=[CH:19][C:15]=1[C:16]([OH:18])=[O:17]>>[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][CH2:3][CH:2]1[CH2:11][NH:12][C:19]1[CH:20]=[N:21][CH:22]=[CH:14][C:15]=1[C:16]([OH:18])=[O:17]

참가 물질

3

반응물 2

HCID 150532-Aminomethyl-1,4-benzodioxaneHCID 3453613-Fluoropyridine-4-carboxylic acid

생성물 1

HCID 867282103-[(2,3-Dihydro-1,4-benzodioxin-2-ylmethyl)amino]pyridine-4-carboxylic acid수율 6%

실험 절차

The title compound was prepared in 6% yield from 2,3-dihydro-1,4-benzodioxin-2-ylmethylamine and 3-fluoroisonicotinic acid according to the procedure for the preparation of Example 3. 1H NMR (400 MHz, DMSO-d6): δ 13.43 (br s, 1H), 8.37 (s, 1H), 7.87 (d, 1H, J=5.0 Hz), 7.77 (br s, 1H), 7.57 (d, 1H, J=5.0 Hz), 6.80-6.90 (m, 4H), 4.37-4.48 (m, 2H), 4.02-4.07 (m, 1H), 3.55-3.75 (m, 2H). [M+H] calc'd for C15H14N2O4, 287. found 287.

출처 및 근거

ORD 기록
ord-62660d70bace4350b6f88c7f131924f6
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447045B2

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