Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloroacetic Acid → 5,6-Dimethyluracil
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloroacetic Acid | HCID 300 | — |
| 반응물 | 5,6-Dimethyl-2-thiouracil | HCID 2736249 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 5,6-Dimethyluracil | HCID 96031 | 81.7% |
반응 단계
A solution of 5,6-dimethyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (14.4 g, 0.09 mol, Step A) and chloroacetic acid (100.0 g, 1.06 mol) in water (43 mL) was refluxed overnight, cooled down to ambient temperature and quenched with water (500 mL). The formed precipitate was collected by filtration and dried to yield 10.3 g (79.7%) of the titled compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.70 (s, 3H) 2.02 (s, 3H) 10.56 (s, 1H) 10.86 (s, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09447051B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-1cf59a9992694d7bb67f93f1ff275d11 |
| 출처 메모 | uspto-grants-2016_09 |