Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Hydroxybenzoic Acid → Benzoic acid, 4-hydroxy-, 2-methylbutyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Hydroxybenzoic Acid | HCID 135 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | (S)-2-methyl-1-butanol | HCID 2723602 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Benzoic acid, 4-hydroxy-, 2-methylbutyl ester | HCID 13530949 | 83% |
반응 단계
4.0 g of p-hydroxybenzoic acid and 12.5 g of (S)-(-)-2-methylbutanol were refluxed for 6 hours in toluene in the presence of sulfuric acid, while the generated water was removed out. Subsequently, the reaction solution was washed with water to remove sulfuric acid out. After the resulting solution was dried and concentrated, the concentrate was purified by column chromatography to obtain 5.0 g of the objective ester compound (liquid state at room temperature, [α]D23 =+4.9° (CHCl3)). (Yield: 83%)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05248446 |
| 출처 데이터셋 | uspto-grants-1993_09 |
| ORD ID | ord-4871f52327694f1cbe2e0f27dd59dbfe |
| 출처 메모 | uspto-grants-1993_09 |