Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 5-Cyclopentyl-1,2-oxazol-3-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 5-(Propan-2-yl)-1,2-oxazol-3-amine | HCID 13334663 | — |
| 반응물 | 2-(2-cyclopentyl-1,3-dioxolan-2-yl)-N'-hydroxyacetimidamide | HCID 86653515 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 5-Cyclopentyl-1,2-oxazol-3-amine | HCID 66201008 | 62% |
반응 단계
According to the procedure described for 5-isopropylisoxazol-3-amine in Example 133A Step 4, 2-(2-cyclopentyl-1,3-dioxolan-2-yl)-N′-hydroxyacetimidamide (1.99 g, 93 mmol) was dissolved in ethanol (2 mL) and acidified with 37% aq. hydrochloric acid to give 5-cyclopentylisoxazol-3-amine (875 mg, 62%) as a white solid. 1H NMR (300 MHz, CDCl3) δ 5.52 (s, 1H), 3.86 (bs, 2H), 3.09-3.04 (m, 1H), 2.04 (d, 2H), 1.75-1.62 (m, 6H); LC-MS (ESI) m/z 153 (M+H)′
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09320739B2 |
| 출처 데이터셋 | uspto-grants-2016_04 |
| ORD ID | ord-8a99f29a9f6a4a1d9068f37b94b32698 |
| 출처 메모 | uspto-grants-2016_04 |