Hydrazine → 4-Hydrazinylpyridin-2(1H)-one

HRID 631653노트

반응식

HRID 631653 반응식
[NH2:1][NH2:2].O[C:4]1[C:5]([OH:10])=[N:6][CH:7]=[CH:8][CH:9]=1>COCCOC>[NH:1]([C:9]1[CH:8]=[CH:7][NH:6][C:5](=[O:10])[CH:4]=1)[NH2:2]

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 178516237HCID 178516237, 화합물

생성물 1

HCID 136108294-Hydrazinylpyridin-2(1H)-one수율 78%

시약·촉매·용매 1

HCID 80711,2-Dimethoxyethane용매

실험 절차

To a solution of hydrazine (8 mL) in DME (40 mL) was added dihydroxypyridine (2.00 g, 18 mmol) and the reaction heated at reflux overnight. The solution was cooled to rt, and the solids removed by filtration. The filtrate was concentrated and the resulting solid crystallized from hot EtOH to afford 4-hydrazinylpyridin-2(1H)-one (1.75 g, 78% yield). LC-MS (ESI) m/z 126 (M+H)+.

후처리

  1. temperaturethe reaction heated
  2. temperatureat reflux overnight
  3. customthe solids removed by filtration
  4. concentrationThe filtrate was concentrated
  5. customthe resulting solid crystallized from hot EtOH

출처 및 근거

ORD 기록
ord-7237a71d73034ee9ab2ff86d01f650e4
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09320739B2

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