Pentanenitrile, 4,4-dimethyl-3-oxo- → HCID 66875928, 화합물

HRID 631741

반응식

HRID 631741 반응식
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][NH2:10].[CH3:13][C:14]([CH3:21])([CH3:20])[C:15](=O)[CH2:16][C:17]#[N:18]>>[C:14]([C:15]1[CH:16]=[C:17]([NH2:18])[N:9]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[C:2]([F:11])([F:12])[F:1])[N:10]=1)([CH3:21])([CH3:20])[CH3:13]

참가 물질

3

반응물 2

HCID 108871Pentanenitrile, 4,4-dimethyl-3-oxo-HCID 5208002-(Trifluoromethyl)phenylhydrazine

생성물 1

HCID 66875928HCID 66875928, 화합물수율 64%

실험 절차

The title compound was prepared from 2-(trifluoromethyl)-phenylhydrazine (1.41 g, 8.0 mmol) and 4,4-dimethyl-3-oxopentanenitrile (1.0 g, 8.0 mmol) using the procedure in Example 161A Step 3 to give 3-tert-butyl-1-(2-(trifluoromethyl)phenyl)-1H-pyrazol-5-amine (1.45 g, 5.12 mmol, 64%). 1H NMR (300 MHz, DMSO-d6) δ 7.86 (d, 1H), 7.75 (t, 1H), 7.65 (t, 1H), 7.49 (d, 1H), 5.27 (s, 1H), 4.97 (s, 1H), 1.18 (s, 9H); LC-MS (ESI) m/z 284 (M+H)+.

출처 및 근거

ORD 기록
ord-2d8a4ed42f8e4e84a5ae251a184e4ff1
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09320739B2

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