Pentanenitrile, 4,4-dimethyl-3-oxo- → 3-(tert-Butyl)-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-5-amine

반응식

Cl.[F:2][C:3]([F:13])([F:12])[C:4]1[CH:5]=[C:6]([NH:10][NH2:11])[CH:7]=[CH:8][CH:9]=1.[CH3:14][C:15]([CH3:22])([CH3:21])[C:16](=O)[CH2:17][C:18]#[N:19]>>[C:15]([C:16]1[CH:17]=[C:18]([NH2:19])[N:10]([C:6]2[CH:7]=[CH:8][CH:9]=[C:4]([C:3]([F:12])([F:13])[F:2])[CH:5]=2)[N:11]=1)([CH3:22])([CH3:21])[CH3:14]

참가 물질

반응물 2

HCID 108871Pentanenitrile, 4,4-dimethyl-3-oxo-

HCID 2733310(3-(Trifluoromethyl)phenyl)hydrazine hydrochloride

생성물 1

HCID 433813053-(tert-Butyl)-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-5-amine수율 30.3%

실험 절차

Following the procedure in Example 161A Step 3, 3-trifluoromethylphenylhydrazine hydrochloride (781 mg, 4.44 mmol) and 4,4-Dimethyl-3-oxopentanenitrile (500 mg, 4.0 mmol) were reacted to give 3-tert-butyl-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-5-amine (344 mg, 1.21 mmol, 30%). No NMR taken. LC-MS (ESI) m/z 284 (M+H)+.

후처리

customwere reacted

출처 및 근거

ORD 기록: ord-4f2d70c326d74828bd0d87f451c1d3c4
출처 데이터셋: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09320739B2

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