N-[2-(1-Benzyl-1H-tetrazol-5-yl)-3-methylphenyl]-benzenesulfonamide → HCID 178425663, 화합물

HRID 631869노트

반응식

HRID 631869 반응식
C([N:8]1[C:12]([C:13]2[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][C:14]=2[NH:20][S:21]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)(=[O:23])=[O:22])=[N:11][N:10]=[N:9]1)C1C=CC=CC=1.[H][H]>C(OCC)(=O)C.[Pd]>[CH3:19][C:18]1[C:13]([C:12]2[NH:8][N:9]=[N:10][N:11]=2)=[C:14]([NH:20][S:21]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)(=[O:23])=[O:22])[CH:15]=[CH:16][CH:17]=1

참가 물질

5

반응물 2

HCID 68296407N-[2-(1-Benzyl-1H-tetrazol-5-yl)-3-methylphenyl]-benzenesulfonamide2회HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 178425663HCID 178425663, 화합물수율 205.7%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

N-[2-(1-Benzyl-1H-tetrazol-5-yl)-3-methylphenyl]-benzenesulfonamide (Intermediate 15, 0.05 g) was dissolved in ethyl acetate (10 mL) under a nitrogen atmosphere. Palladium on carbon (10%, 0.02 g) was added and the nitrogen atmosphere was replaced by hydrogen. The mixture was stirred for 7 days and then filtered through celite and the solvent was removed by evaporation under vacuum. The residue was purified by preparative HPLC (C18). The fractions containing the desired product were combined, and the solvent was removed by evaporation to give the title compound as a white solid (0.08 g).

후처리

  1. filtrationfiltered through celite
  2. customthe solvent was removed by evaporation under vacuum
  3. customThe residue was purified by preparative HPLC (C18)
  4. additionThe fractions containing the desired product
  5. customthe solvent was removed by evaporation

출처 및 근거

ORD 기록
ord-7a9862ae3bd248a8bc9dcdde75e4bf02
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09321740B2

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