6-(3-Chlorophenyl)picolinic acid → 6-(3-Chloro-phenyl)-pyridine-2-carboxylic acid (1-methyl-1-oxazol-2-yl-ethyl)-amide

반응식

[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[CH3:17][C:18]([CH3:25])([C:20]1[O:21][CH:22]=[CH:23][N:24]=1)[NH2:19]>>[CH3:17][C:18]([NH:19][C:14]([C:12]1[CH:11]=[CH:10][CH:9]=[C:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[N:13]=1)=[O:16])([C:20]1[O:21][CH:22]=[CH:23][N:24]=1)[CH3:25]

참가 물질

반응물 2

HCID 247301356-(3-Chlorophenyl)picolinic acid

HCID 82418817alpha,alpha-Dimethyl-2-oxazolemethanamine

생성물 1

HCID 711055376-(3-Chloro-phenyl)-pyridine-2-carboxylic acid (1-methyl-1-oxazol-2-yl-ethyl)-amide

실험 절차

The title compound was synthesized in analogy to Example 1, using 6-(3-chlorophenyl)-2-pyridinecarboxylic acid (CAN 863704-38-5) and α,α-dimethyl-2-oxazolemethanamine (CAN 1211519-76-4) as starting materials, MS (LC/MS): 341.9 [M+H]+.

출처 및 근거

ORD 기록: ord-d9fcb0abf9f143eeac00ba5fcb0454a2
출처 데이터셋: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09321727B2

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