1,1-Dimethoxyethyl(dimethyl)amine → HCID 86674739, 화합물

HRID 631988노트

반응식

HRID 631988 반응식
[NH2:1][C:2](=[S:14])[C:3]([NH:6][C:7](=[O:13])[O:8][C:9]([CH3:12])([CH3:11])[CH3:10])([CH3:5])[CH3:4].CO[C:17](OC)([N:19]([CH3:21])[CH3:20])[CH3:18]>C(Cl)Cl>[C:9]([O:8][C:7](=[O:13])[NH:6][C:3]([CH3:5])([CH3:4])[C:2]([N:1]=[C:17]([N:19]([CH3:21])[CH3:20])[CH3:18])=[S:14])([CH3:12])([CH3:11])[CH3:10]

참가 물질

4

반응물 2

HCID 878351,1-Dimethoxyethyl(dimethyl)amineHCID 15186362tert-butyl N-(1-carbamothioyl-1-methylethyl)carbamate

생성물 1

HCID 86674739HCID 86674739, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of tert-butyl 1-amino-2-methyl-1-thioxopropan-2-ylcarbamate (Example 12 b, 0.218 g, 1 mmol) and 1,1-dimethoxy-N,N-dimethylethanamine (CAN 18871-66-4, 0.16 g, 1.2 mmol) in methylene chloride (10 mL) was stirred at room temperature for 24 h. Then it was concentrated to give crude product, which was used directly in the next step without further purification (0.28 g, 98%) as yellow oil; MS (EI): m/e 288.2 [M+H]+.

후처리

  1. concentrationThen it was concentrated
  2. customto give crude product, which
  3. customwas used directly in the next step without further purification (0.28 g, 98%) as yellow oil

출처 및 근거

ORD 기록
ord-156fc019b4e94d5ba01455d015a12e21
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09321727B2

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