6-Cyclopropylmethoxy-5-(2-oxo-pyrrolidin-1-yl)-pyridine-2-carboxylic acid → 6-Cyclopropylmethoxy-5-(2-oxo-pyrrolidin-1-yl)-pyridine-2-carboxylic acid (1-methyl-1-oxazol-2-yl-ethyl)-amide

HRID 632066노트

반응식

HRID 632066 반응식
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[N:15]2[CH2:19][CH2:18][CH2:17][C:16]2=[O:20])[CH2:3][CH2:2]1.[CH3:21][C:22]([CH3:29])([C:24]1[O:25][CH:26]=[CH:27][N:28]=1)[NH2:23]>>[CH3:21][C:22]([NH:23][C:12]([C:10]1[CH:9]=[CH:8][C:7]([N:15]2[CH2:19][CH2:18][CH2:17][C:16]2=[O:20])=[C:6]([O:5][CH2:4][CH:1]2[CH2:2][CH2:3]2)[N:11]=1)=[O:14])([C:24]1[O:25][CH:26]=[CH:27][N:28]=1)[CH3:29]

참가 물질

3

반응물 2

HCID 710875066-Cyclopropylmethoxy-5-(2-oxo-pyrrolidin-1-yl)-pyridine-2-carboxylic acidHCID 82418817alpha,alpha-Dimethyl-2-oxazolemethanamine

생성물 1

HCID 710935876-Cyclopropylmethoxy-5-(2-oxo-pyrrolidin-1-yl)-pyridine-2-carboxylic acid (1-methyl-1-oxazol-2-yl-ethyl)-amide

실험 절차

The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-(2-oxo-pyrrolidin-1-yl)-pyridine-2-carboxylic acid and α,α-dimethyl-2-oxazolemethanamine (CAN 1211519-76-4) as starting materials, MS (EI): m/e=358.2 [M+H]+.

출처 및 근거

ORD 기록
ord-7707d0a2b2e840ecae5a4805e496231a
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09321727B2

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