2-(1,2,4-Oxadiazol-3-yl)propan-2-amine → 5-Chloro-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (1-methyl-1-[1,2,4]oxadiazol-3-yl-ethyl)-amide

반응식

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:13]([OH:15])=O)=[N:6][C:7]=1[O:8][CH2:9][CH:10]1[CH2:12][CH2:11]1.[CH3:16][C:17]([NH2:24])([C:19]1[N:23]=[CH:22][O:21][N:20]=1)[CH3:18]>>[CH3:16][C:17]([NH:24][C:13]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[C:7]([O:8][CH2:9][CH:10]2[CH2:11][CH2:12]2)[N:6]=1)=[O:15])([C:19]1[N:23]=[CH:22][O:21][N:20]=1)[CH3:18]

참가 물질

반응물 2

HCID 435591182-(1,2,4-Oxadiazol-3-yl)propan-2-amine

HCID 710876525-Chloro-6-cyclopropylmethoxy-pyridine-2-carboxylic acid

생성물 1

HCID 710936395-Chloro-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (1-methyl-1-[1,2,4]oxadiazol-3-yl-ethyl)-amide

실험 절차

The title compound was synthesized in analogy to Example 1, using 5-chloro-6-cyclopropylmethoxy-pyridine-2-carboxylic acid and 1-methyl-1-[1,2,4]oxadiazol-3-yl ethylamine (CAN 1153757-41-5) as starting materials, MS (LC/MS): m/e=337.1 [M+H]+.

출처 및 근거

ORD 기록: ord-fed37a570ac34472a81ec9acc4b35681
출처 데이터셋: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09321727B2

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