2-(1,2,4-Oxadiazol-3-yl)propan-2-amine → 5-Chloro-6-(3-chloro-phenyl)-pyridine-2-carboxylic acid (1-methyl-1-[1,2,4]oxadiazol-3-yl-ethyl)-amide

HRID 632106노트

반응식

HRID 632106 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:15]([OH:17])=O)=[N:6][C:7]=1[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([Cl:14])[CH:9]=1.[CH3:18][C:19]([NH2:26])([C:21]1[N:25]=[CH:24][O:23][N:22]=1)[CH3:20]>>[CH3:18][C:19]([NH:26][C:15]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([Cl:14])[CH:9]=2)[N:6]=1)=[O:17])([C:21]1[N:25]=[CH:24][O:23][N:22]=1)[CH3:20]

참가 물질

3

반응물 2

HCID 435591182-(1,2,4-Oxadiazol-3-yl)propan-2-amineHCID 710876195-Chloro-6-(3-chloro-phenyl)-pyridine-2-carboxylic acid

생성물 1

HCID 711055865-Chloro-6-(3-chloro-phenyl)-pyridine-2-carboxylic acid (1-methyl-1-[1,2,4]oxadiazol-3-yl-ethyl)-amide

실험 절차

The title compound was synthesized in analogy to Example 1, using 5-chloro-6-(3-chloro-phenyl)-pyridine-2-carboxylic acid (Example 58 c) and 1-methyl-1-[1,2,4]oxadiazol-3-yl ethylamine (CAN 1153757-41-5) as starting materials, MS (EI): m/e=377.0 [M+H]+.

출처 및 근거

ORD 기록
ord-1bf51d043c384e41a0ddb9e25e98958c
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09321727B2

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