6-Cyclopentenyl-pyridine-2-carboxylic acid → 6-Cyclopentyl-pyridine-2-carboxylic acid

HRID 632113노트

반응식

HRID 632113 반응식
[C:1]1([C:6]2[N:11]=[C:10]([C:12]([OH:14])=[O:13])[CH:9]=[CH:8][CH:7]=2)[CH2:5][CH2:4][CH2:3][CH:2]=1.[H][H]>[Pd].C(O)C>[CH:1]1([C:6]2[N:11]=[C:10]([C:12]([OH:14])=[O:13])[CH:9]=[CH:8][CH:7]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1

참가 물질

5

반응물 2

HCID 866747586-Cyclopentenyl-pyridine-2-carboxylic acidHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 866747596-Cyclopentyl-pyridine-2-carboxylic acid수율 99.6%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of 6-cyclopentenyl-pyridine-2-carboxylic acid (0.08 g, 0.42 mmol) and palladium on carbon (10% w/w, 0.04 g, 0.3 mmol) in ethanol (10 mL) was charged with a hydrogen balloon and stirred at room temperature overnight. The reaction mixture was filtered and the filtrate was concentrated to obtain the crude product as white solid (0.08 g, 99%) which was used directly in the next step without further purification; MS (EI): m/e=192.2 [M+H]+.

후처리

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-4d38f164c2e245a5a609904cdc05383f
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09321727B2

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