(S)-alpha-amino-cyclopropanepropanamide → 5-Bromo-6-cyclopropylmethoxy-pyridine-2-carboxylic acid ((S)-1-carbamoyl-2-cyclopropyl-ethyl)-amide

HRID 632137

반응식

HRID 632137 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:13]([OH:15])=O)=[N:6][C:7]=1[O:8][CH2:9][CH:10]1[CH2:12][CH2:11]1.[NH2:16][C@@H:17]([CH2:21][CH:22]1[CH2:24][CH2:23]1)[C:18]([NH2:20])=[O:19]>>[C:18]([C@@H:17]([NH:16][C:13]([C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[C:7]([O:8][CH2:9][CH:10]2[CH2:11][CH2:12]2)[N:6]=1)=[O:15])[CH2:21][CH:22]1[CH2:24][CH2:23]1)(=[O:19])[NH2:20]

참가 물질

3

반응물 2

HCID 53964035(S)-alpha-amino-cyclopropanepropanamideHCID 710875435-Bromo-6-cyclopropylmethoxy-pyridine-2-carboxylic acid

생성물 1

HCID 711055975-Bromo-6-cyclopropylmethoxy-pyridine-2-carboxylic acid ((S)-1-carbamoyl-2-cyclopropyl-ethyl)-amide

실험 절차

The title compound was synthesized in analogy to Example 1, using 5-bromo-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 9 d) and (S)-2-amino-3-cyclopropyl-propionamide (CAN 156077-93-9) as starting materials, MS (EI): m/e=382.0 [M+H]+.

출처 및 근거

ORD 기록
ord-fc8d600890234b2eb4042a17e3d6823c
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09321727B2

연결된 노트

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