6-(3-Chloro-phenyl)-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid → 6-(3-Chloro-phenyl)-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid [(S)-2-cyclopropyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethyl]-amide

HRID 632223

반응식

HRID 632223 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[C:12]([C:14](O)=[O:15])[CH:11]=[CH:10][C:9]=2[N:17]2[CH2:20][C:19]([F:22])([F:21])[CH2:18]2)[CH:5]=[CH:6][CH:7]=1.[CH:23]1([CH2:26][C@H:27]([NH2:34])[C:28]2[N:32]=[C:31]([CH3:33])[O:30][N:29]=2)[CH2:25][CH2:24]1>>[CH:23]1([CH2:26][C@H:27]([NH:34][C:14]([C:12]2[CH:11]=[CH:10][C:9]([N:17]3[CH2:20][C:19]([F:21])([F:22])[CH2:18]3)=[C:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)[N:13]=2)=[O:15])[C:28]2[N:32]=[C:31]([CH3:33])[O:30][N:29]=2)[CH2:25][CH2:24]1

참가 물질

3

반응물 2

HCID 710876736-(3-Chloro-phenyl)-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acidHCID 86674748(S)-2-Cyclopropyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethylamine

생성물 1

HCID 711056386-(3-Chloro-phenyl)-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid [(S)-2-cyclopropyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethyl]-amide

실험 절차

The title compound was synthesized in analogy to Example 1, using 6-(3-chloro-phenyl)-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 140 a) and (S)-2-cyclopropyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethylamine (Example 38 e) as starting materials, MS (EI): m/e=474.1 [M+H]+.

출처 및 근거

ORD 기록
ord-e03a8cd7e0fb4bb8acf134b82c74750c
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09321727B2

연결된 노트

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