Potassium cyclopropyltrifluoroborate → N-((S)-1-amino-4-methyl-1-oxopentan-2-yl)-5-cyclopropyl-6-((tetrahydrofuran-2-yl)methoxy)picolinamide

HRID 632248

반응식

HRID 632248 반응식
[C:1]([C@@H:4]([NH:9][C:10]([C:12]1[CH:17]=[CH:16][C:15](Br)=[C:14]([O:19][CH2:20][CH:21]2[CH2:25][CH2:24][CH2:23][O:22]2)[N:13]=1)=[O:11])[CH2:5][CH:6]([CH3:8])[CH3:7])(=[O:3])[NH2:2].[CH:26]1([B-](F)(F)F)[CH2:28][CH2:27]1.[K+]>>[NH2:2][C:1](=[O:3])[C@@H:4]([NH:9][C:10](=[O:11])[C:12]1[CH:17]=[CH:16][C:15]([CH:26]2[CH2:28][CH2:27]2)=[C:14]([O:19][CH2:20][CH:21]2[CH2:25][CH2:24][CH2:23][O:22]2)[N:13]=1)[CH2:5][CH:6]([CH3:8])[CH3:7]

참가 물질

3

반응물 2

HCID 23697338Potassium cyclopropyltrifluoroborateHCID 711056435-Bromo-6-(tetrahydro-furan-2-ylmethoxy)-pyridine-2-carboxylic acid ((S)-1-carbamoyl-3-methyl-butyl)-amide

생성물 1

HCID 71087442N-((S)-1-amino-4-methyl-1-oxopentan-2-yl)-5-cyclopropyl-6-((tetrahydrofuran-2-yl)methoxy)picolinamide

실험 절차

The title compound was synthesized in analogy to Example 166 b, using 5-bromo-6-(tetrahydro-furan-2-ylmethoxy)-pyridine-2-carboxylic acid ((S)-1-carbamoyl-3-methyl-butyl)-amide (Example 186 a) and potassium cyclopropyltrifluoroborate as starting materials, MS (EI): m/e=376.2 [M+H]+.

출처 및 근거

ORD 기록
ord-59c5b9a56c814ad99fe410e364a28697
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09321727B2

연결된 노트

불러오는 중…