(2S)-2-Amino-N,3,3-trimethylbutanamide → 5-Bromo-6-(tetrahydro-furan-2-ylmethoxy)-pyridine-2-carboxylic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide

HRID 632250

반응식

HRID 632250 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:15]([OH:17])=O)=[N:6][C:7]=1[O:8][CH2:9][CH:10]1[CH2:14][CH2:13][CH2:12][O:11]1.[NH2:18][C@@H:19]([C:24]([CH3:27])([CH3:26])[CH3:25])[C:20]([NH:22][CH3:23])=[O:21]>>[CH3:25][C:24]([CH3:27])([CH3:26])[C@H:19]([NH:18][C:15]([C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[C:7]([O:8][CH2:9][CH:10]2[CH2:14][CH2:13][CH2:12][O:11]2)[N:6]=1)=[O:17])[C:20](=[O:21])[NH:22][CH3:23]

참가 물질

3

반응물 2

HCID 445856(2S)-2-Amino-N,3,3-trimethylbutanamideHCID 710877285-Bromo-6-(tetrahydro-furan-2-ylmethoxy)-pyridine-2-carboxylic acid

생성물 1

HCID 711056445-Bromo-6-(tetrahydro-furan-2-ylmethoxy)-pyridine-2-carboxylic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide

실험 절차

The title compound was synthesized in analogy to Example 1, using 5-bromo-6-(tetrahydro-furan-2-ylmethoxy)-pyridine-2-carboxylic acid (Example 166 a) and (2S)-2-amino-N,3,3-trimethyl-butanamide, (CAN 89226-12-0) as starting materials, MS (EI): m/e=428.0 [M+H]+.

출처 및 근거

ORD 기록
ord-c6ee2b9a4dfe42b4a596bf7923a131a3
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09321727B2

연결된 노트

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