6-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid → 2-[(6-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carbonyl)-amino]-2-ethyl-butyric acid methyl ester

HRID 632305

반응식

HRID 632305 반응식
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[C:15]([F:18])([F:17])[F:16])[CH2:3][CH2:2]1.Cl.[NH2:20][C:21]([CH2:28][CH3:29])([CH2:26][CH3:27])[C:22]([O:24][CH3:25])=[O:23]>>[CH3:25][O:24][C:22](=[O:23])[C:21]([NH:20][C:12]([C:10]1[CH:9]=[CH:8][C:7]([C:15]([F:18])([F:17])[F:16])=[C:6]([O:5][CH2:4][CH:1]2[CH2:2][CH2:3]2)[N:11]=1)=[O:14])([CH2:28][CH3:29])[CH2:26][CH3:27]

참가 물질

3

반응물 2

HCID 710874576-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acidHCID 75488114Methyl 2-amino-2-ethylbutanoate hydrochloride

생성물 1

HCID 710872092-[(6-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carbonyl)-amino]-2-ethyl-butyric acid methyl ester

실험 절차

The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid (Example 113 d) and methyl 2-amino-2-ethylbutanoate hydrochloride (CAN 92398-54-4) as starting materials. MS (EI): m/e=389.0 [M+H]+.

출처 및 근거

ORD 기록
ord-5d1700ab6b57418fac251c5a0839f33a
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09321727B2

연결된 노트

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