Ethyl 2-amino-2-ethylbutanoate hydrochloride → 2-{[6-Cyclopropylmethoxy-5-(6-oxa-1-aza-spiro[3.3]hept-1-yl)-pyridine-2-carbonyl]-amino}-2-ethyl-butyric acid ethyl ester

HRID 632320

반응식

HRID 632320 반응식
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12](O)=[O:13])[CH:9]=[CH:8][C:7]=2[N:15]2[C:18]3([CH2:21][O:20][CH2:19]3)[CH2:17][CH2:16]2)[CH2:3][CH2:2]1.Cl.[NH2:23][C:24]([CH2:32][CH3:33])([CH2:30][CH3:31])[C:25]([O:27][CH2:28][CH3:29])=[O:26]>>[CH2:28]([O:27][C:25](=[O:26])[C:24]([NH:23][C:12]([C:10]1[CH:9]=[CH:8][C:7]([N:15]2[C:18]3([CH2:21][O:20][CH2:19]3)[CH2:17][CH2:16]2)=[C:6]([O:5][CH2:4][CH:1]2[CH2:2][CH2:3]2)[N:11]=1)=[O:13])([CH2:32][CH3:33])[CH2:30][CH3:31])[CH3:29]

참가 물질

3

반응물 2

HCID 24201639Ethyl 2-amino-2-ethylbutanoate hydrochlorideHCID 71087704HCID 71087704, 화합물

생성물 1

HCID 710878402-{[6-Cyclopropylmethoxy-5-(6-oxa-1-aza-spiro[3.3]hept-1-yl)-pyridine-2-carbonyl]-amino}-2-ethyl-butyric acid ethyl ester

실험 절차

The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-(6-oxa-1-aza-spiro[3.3]hept-1-yl)-pyridine-2-carboxylic acid (Example 234 b) and ethyl 2-amino-2-ethylbutanoate hydrochloride (CAN 1135219-29-2) as starting materials. MS (EI): m/e=432.3 [M+H]+.

출처 및 근거

ORD 기록
ord-040b908b083e4f7c9d2c7fa8a6761b49
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09321727B2

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