3,3-Difluoroazetidine hydrochloride → HCID 71105690, 화합물

HRID 632346노트

반응식

HRID 632346 반응식
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:15]([NH:17][C:18]([CH2:24][CH3:25])([CH2:22][CH3:23])[C:19]([OH:21])=O)=[O:16])=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.Cl.[F:27][C:28]1([F:32])[CH2:31][NH:30][CH2:29]1>>[F:27][C:28]1([F:32])[CH2:31][N:30]([C:19]([C:18]([NH:17][C:15]([C:7]2[CH:6]=[CH:5][C:4]([CH:1]3[CH2:3][CH2:2]3)=[C:9]([O:10][CH2:11][CH:12]3[CH2:14][CH2:13]3)[N:8]=2)=[O:16])([CH2:24][CH3:25])[CH2:22][CH3:23])=[O:21])[CH2:29]1

참가 물질

3

반응물 2

HCID 27582473,3-Difluoroazetidine hydrochlorideHCID 710875422-(5-Cyclopropyl-6-(cyclopropylmethoxy)picolinamido)-2-ethylbutanoic acid

생성물 1

HCID 71105690HCID 71105690, 화합물

실험 절차

The title compound was synthesized in analogy to Example 1, using 2-(5-cyclopropyl-6-(cyclopropylmethoxy)picolinamido)-2-ethylbutanoic acid (Example 274 a) and 3,3-difluoroazetidine hydrochloride (CAN 288315-03-7) as starting materials. MS (EI): m/e=422.0 [M+H]+.

출처 및 근거

ORD 기록
ord-74f6a199f54942e490430a6f47fc92b5
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09321727B2

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