5-Cyclopropyl-6-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid → 5-Cyclopropyl-6-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (3-thiazol-2-yl-oxetan-3-yl)-amide
반응식
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:16]([OH:18])=O)=[N:8][C:9]=2[O:10][CH2:11][C:12]([F:15])([F:14])[F:13])[CH2:3][CH2:2]1.Cl.[S:20]1[CH:24]=[CH:23][N:22]=[C:21]1[C:25]1([NH2:29])[CH2:28][O:27][CH2:26]1>>[S:20]1[CH:24]=[CH:23][N:22]=[C:21]1[C:25]1([NH:29][C:16]([C:7]2[CH:6]=[CH:5][C:4]([CH:1]3[CH2:2][CH2:3]3)=[C:9]([O:10][CH2:11][C:12]([F:13])([F:14])[F:15])[N:8]=2)=[O:18])[CH2:28][O:27][CH2:26]1참가 물질
3
실험 절차
The title compound was synthesized in analogy to Example 280c, using 5-cyclopropyl-6-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (Example 301a) and 3-(thiazol-2-yl)oxetan-3-amine hydrochloride (Example 281b) as starting materials, MS (EI): m/e=400.1 [M+H]+.
출처 및 근거
- ORD 기록
- ord-940eda2ae34341d09bdf67da1e31b6c5
- 출처 데이터셋
- uspto-grants-2016_04