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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 632383생성일: 2026년 10월 25일

3,3-Difluoroazetidine hydrochloride → 6-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid [1-(3,3-difluoro-azetidine-1-carbonyl)-1-ethyl-propyl]-amide

https://huagongshe.com/reaction/632383

반응식

참여 물질

역할이름HCID투입량
반응물3,3-Difluoroazetidine hydrochlorideHCID 2758247—
반응물2-(6-(Cyclopropylmethoxy)-5-(trifluoromethyl)picolinamido)-2-ethylbutanoic acidHCID 71087462—
생성물6-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid [1-(3,3-difluoro-azetidine-1-carbonyl)-1-ethyl-propyl]-amideHCID 71105699—

반응 단계

In analogy to the procedure described in Example 293, 2-[(6-cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carbonyl)-amino]-2-ethyl-butyric acid (Example 252 b) and 3,3-difluoroazetidine hydrochloride (CAN 288315-03-7) were condensed to the title product. MS (EI): m/e=450.0 [M+H]+.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09321727B2
출처 데이터셋uspto-grants-2016_04
ORD IDord-f75e2e24f39747f384ca6d4808f36ec6
출처 메모uspto-grants-2016_04