Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
L-Leucine, ethyl ester, hydrochloride (1:1) → (S)-Ethyl 2-(5-cyclopropyl-6-(4-fluorobenzyl)picolinamido)-4-methylpentanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | L-Leucine, ethyl ester, hydrochloride (1:1) | HCID 11658447 | — |
| 반응물 | 5-Cyclopropyl-6-(4-fluoro-benzyl)-pyridine-2-carboxylic acid | HCID 71087698 | — |
| 생성물 | (S)-Ethyl 2-(5-cyclopropyl-6-(4-fluorobenzyl)picolinamido)-4-methylpentanoate | HCID 86674796 | — |
반응 단계
The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-(4-fluoro-benzyl)-pyridine-2-carboxylic acid (Example 155 g) and (S)-ethyl 2-amino-4-methylpentanoate hydrochloride (CAN 2743-40-0) as starting materials. MS (EI): m/e=413.2 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09321727B2 |
| 출처 데이터셋 | uspto-grants-2016_04 |
| ORD ID | ord-81e44c6fdb6e48aab7c1ad8daac01290 |
| 출처 메모 | uspto-grants-2016_04 |