4-Methanesulfonyl-2-methylbutan-2-amine → 5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (3-methanesulfonyl-1,1-dimethyl-propyl)-amide
반응식
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.[CH3:18][C:19]([NH2:27])([CH2:21][CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH3:20]>>[CH3:26][S:23]([CH2:22][CH2:21][C:19]([NH:27][C:15]([C:7]1[CH:6]=[CH:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[N:8]=1)=[O:17])([CH3:20])[CH3:18])(=[O:25])=[O:24]참가 물질
3
실험 절차
The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-cyclopropylmethyloxy-pyridine-2-carboxylic acid (Example 42a) and 2-methyl-4-(methylsulfonyl)-2-butanamine (CAN 1250515-16-2) as starting materials; LC-MS (UV peak area/ESI) 95%, 381.1843 (M+H)+.
출처 및 근거
- ORD 기록
- ord-09ea6b52fe9b47ada5a59f47923871c0
- 출처 데이터셋
- uspto-grants-2016_04