1-(Trifluoromethyl)cyclopropanamine → HCID 71105762, 화합물

반응식

[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[N:15]2[CH2:18][C:17]([F:20])([F:19])[CH2:16]2)[CH2:3][CH2:2]1.[F:21][C:22]([F:28])([F:27])[C:23]1([NH2:26])[CH2:25][CH2:24]1>>[F:21][C:22]([F:28])([F:27])[C:23]1([NH:26][C:12]([C:10]2[CH:9]=[CH:8][C:7]([N:15]3[CH2:18][C:17]([F:20])([F:19])[CH2:16]3)=[C:6]([O:5][CH2:4][CH:1]3[CH2:2][CH2:3]3)[N:11]=2)=[O:14])[CH2:25][CH2:24]1

참가 물질

반응물 2

HCID 116511971-(Trifluoromethyl)cyclopropanamine

HCID 710872926-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid

생성물 1

HCID 71105762HCID 71105762, 화합물

실험 절차

The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 69 b) and 1-(trifluoromethyl)cyclopropanamine (CAN 112738-68-8) as starting materials. MS (EI): m/e=392.4 [M+H]+.

출처 및 근거

ORD 기록: ord-3aa7776220864071a19b3da31adbdb13
출처 데이터셋: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09321727B2

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