Water → 5-(Benzyloxy)-2-bromopyridine
반응식
[Br:1][C:2]1[N:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:15](Br)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.O>CN(C=O)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:6][N:7]=1참가 물질
6
반응 조건
- 온도
- 15 °C
실험 절차
To a stirred solution of 6-bromo-3-pyridinol (10 g, Commercial eg Apollo Scientific Ltd.) in DMF (100 ml) was added potassium carbonate (17.8 g). The reaction mixture was stirred for 15 min at 25-30 C. before cooling to 15° C. To this was added slowly benzyl bromide (7.5 ml) and this was stirred at 25-30° C. for 48 h. The reaction mixture was poured into cold water and the solid was collected by filtration to give the title compound, 14.5 g
후처리
- stirringthis was stirred at 25-30° C. for 48 h
- filtrationthe solid was collected by filtration
출처 및 근거
- ORD 기록
- ord-8f299c5ebbfe49debf190fa8ba112a87
- 출처 데이터셋
- uspto-grants-2016_09
- 특허 번호
- US09447074B2
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